Methyl isocyanate: reproductive and developmental toxicology studies in Swiss mice.

Overview of reproductive and developmental toxicity studies of 1,3-butadiene in rodents.

A series of studies to further evaluate the developmental and reproductive toxicity of inhaled 1,3-butadiene was sponsored by the National Toxicology Program. Pregnant Sprague-Dawley rats (24-28/group) and Swiss (CD-1) mice (18-22/group) were exposed to atmospheric concentrations of 0, 40, 200, or 1000 ppm 1,3-butadiene for 6 hr/day on days 6 through 15 of gestation (dg) and killed on dg 18 (mi...

Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy.

Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journals for several months after the accident. We therefore conducted, 9 months afte...

Reproductive toxicology. Feed restriction in Swiss CD-1 mice.

Toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies.

Male and female F344/N rats and B6C3F1 mice were exposed to lethal and sublethal concentrations of methyl isocyanate by inhalation. Mortality, clinical signs, body and organ weights, and changes in clinical pathology and hematology were monitored immediately after 2-hr exposures and during the ensuing 3 months. Additional studies investigated the possible involvement of cyanide in the toxicity ...

Evaluation of the Extracts From Rhizomes of Polygonum bistorta for the Median Lethal Dosages in Swiss Albino Mice

Background: Polygonum bistorta has been used as a remedy for jaundice, smallpox, pimples, measles, cholera, diarrhoea, dysentery, expelling worms, insect stings and snakebites. In this study, the crude extract from P. bistorta and two fractions viz. hexane and chloroform obtained from the crude extract were studied for their median lethal dosages (LD50) in Swiss albino mice. Methods: Powdered ...